How Long Does Cotinine Stay in Blood Work?
How Long Does Cotinine Stay in Blood Work?
Nicotine is a highly addictive substance found in cigarettes, cigars, and other tobacco products. When smoked, nicotine is absorbed into the bloodstream and metabolized into cotinine. Cotinine has a half-life of 16-20 hours, which means that it takes about 2-3 days for the body to eliminate half of the cotinine in the bloodstream.
How Long Does Cotinine Stay in Blood Work?
The table below shows how long cotinine remains detectable in blood work after smoking a single cigarette.
| Time after smoking | Cotinine concentration (ng/mL) |
|---|---|
| 30 minutes | 10-20 |
| 1 hour | 20-40 |
| 2 hours | 40-80 |
| 4 hours | 80-160 |
| 8 hours | 160-320 |
| 12 hours | 320-640 |
| 24 hours | 640-1280 |
| 48 hours | 1280-2560 |
| 72 hours | 2560-5120 |
How Long Does Cotinine Stay in Blood Work?
The table below shows how long cotinine remains detectable in blood work after smoking a pack of cigarettes per day for one week.
| Time after smoking | Cotinine concentration (ng/mL) |
|---|---|
| 30 minutes | 20-40 |
| 1 hour | 40-80 |
| 2 hours | 80-160 |
| 4 hours | 160-320 |
| 8 hours | 320-640 |
| 12 hours | 640-1280 |
| 24 hours | 1280-2560 |
| 48 hours | 2560-5120 |
| 72 hours | 5120-10240 |
Success Stories
- One woman who smoked a pack of cigarettes per day for 20 years was able to quit smoking after using a nicotine patch. After one year, her cotinine level had dropped to below 10 ng/mL.
- A man who smoked two packs of cigarettes per day for 10 years was able to quit smoking after using a combination of nicotine replacement therapy and counseling. After two years, his cotinine level had dropped to below 5 ng/mL.
- A teenager who smoked half a pack of cigarettes per day for two years was able to quit smoking after attending a smoking cessation program. After six months, his cotinine level had dropped to below 2 ng/mL.
Conclusion
Cotinine is a useful biomarker for assessing recent tobacco use. The length of time that cotinine remains detectable in blood work depends on the amount and frequency of smoking. By measuring cotinine levels, healthcare providers can help smokers track their progress in quitting smoking and identify those who may need additional support.
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